This book constitutes the proceedings of the 5th International Symposium on Dependable Software Engineering: Theories, Tools, and Applications, SETTA 2019, held in Shanghai, China, in November 2019. The 8 full papers presented were carefully reviewed and selected from 26 submissions. They present cutting-edge advancements in the field of formal methods and its interoperability with software engineering and focus on the application of formal techniques and tools for building reliable, safe, secure, and smart systems with multi-dimensional complexities. .