Introduction -- Part I: Theoretical Aspects -- Theoretical issues related to designing and developing Teaching-Learning Sequences, Psillos, D., Kariotoglou, P. -- Pragmatic Design-based research - Designing as a shared activity of teachers and researches, Juuti, K., Lavonen, J. -- Participatory Approaches to Curriculum Design within a design-research perspective., Couso, D. -- Part II: Aspects of Materials Science and their educational adaptation -- Materials Science: Trends, Material Properties and ducational Perspectives, Hatzikraniotis, E., Kyratsi Th. -- Integrating Science and Technology in school practice through the educational reconstruction of contents, Testa, I., Lombardi, S., Monroy, S., Sassi, E. -- Part III: Case Studies -- The Process of Iterative Development of a Teaching/Learning Sequence on Acoustic Properties of Materials, Hernandez, M., Pinto, R. -- The evolutionary refinement process of a Teaching Learning Sequence for introducing inquiry aspects and density as materials’ property in floating / sinking phenomena, Zoupidis, A., Spyrtou, A., Malandrakis, G., Kariotoglou, P. -- Design and Development of Teaching-Learning Sequence (TLS) Materials around Us: Description of an Iterative Process, Loukomies, A., Lavonen, J., Juuti, K., Meisalo, V., Lampiselkä, J. -- The iterative design of a Teaching-Learning Sequence on Optical Properties of Materials to integrate Science and Technology, Testa I., Monroy G. -- The iterative evolution of a Teaching-Learning Sequence on the thermal conductivity of materials, Psillos, D., Molohidis, A., Kallery, M., Hatzikraniotis, E. -- DeDesign, Development and Refinement of a Teaching-Learning Sequence on the Electromagnetic Properties of Materials, Papadouris, N., Constantinou, C., Papaevripidou, M., Lividjis, M., Scholinaki, A., Hadjilouca, R. -- Concluding Remarks: Science Education Research for Enhancing Classroom Learning, Constantinou, C.P. , Psillos, D., Kariotoglou, P.