This book constitutes the refereed proceedings of the 22nd International Static Analysis Symposium, SAS 2015, held in Saint-Malo, France, in September 2015. The 18 papers presented in this volume were carefully reviewed and selected from 44 submissions. All fields of static analysis as a fundamental tool for program verification, bug detection, compiler optimization, program understanding, and software maintenance are addressed, featuring theoretical, practical, and application advances in the area.