Introduction: Reliability of Technologies -- Service Life Prediction in the Design Phase -- Assessment of the Residual Life -- Elements of Theory of Probability -- Random Events and Random Variables -- Statistics of Random Variables. Probability Distributions -- Evaluation of Statistics of a Random Process -- Basics of Statistical Dynamics. Spectral Method -- Elements of Spectral Analysis of a Stationary Random Process -- Forced oscillations of a single degree of freedom dynamic system -- Wiener-Khinchin Theorem. Evaluation of the Output Process Statistics -- Service Loads -- Classification of Service Loads on Structures -- Service Loads – Continuous Successions. Spectral and Statistical Characrerization -- Spectral Characterization of Loads -- Fatigue Behavior of Materials and Structural Components -- Fatigue Characterization of Structural Materials -- Principles of Modeling Fatigue Behavior of Structures -- Current Approaches to Fatigue of Structures in Design and in Service Conditions -- Numerical Examples -- Residual Life Assessment of Structures when Fatigue Cracks are Detected -- Effect of Fatigue Cracks on the Service Life Assessment of Structures -- Modeling of Fatigue Crack Propagation in Structures -- Evaluation of Residual Life Numerical Examples -- Criteria for Critical Conditions of Structures -- Instable Fracture of Cracked Structures -- Griffith-Irvin Theory. Experimental Evaluation of Criteria for Fracture -- Alternative Approaches to Fatigue Life Assessment of Structures -- The Damage Accumulation Methodology in Conjunction with the FE-modeling -- The Prospects of Combining the Damage Accumulation and Linear Fracture Mechanics Methodologies -- Numerical Examples -- Principles of Organizing the In-Service Reliability of Structures -- Techniques of Experimental Evaluation of the Reliability Parameters -- Principles of Monitoring the In-Service Reliability of Structures.