This case book provides examples of multi-stakeholder partnerships that aim to create sustainable enterprises for both the for-profit sectors and for individuals who live in conditions of poverty. Ideal for teaching, after a brief introduction to the case method, the cases are presented as descriptions with no comments or criticisms. The cases are arranged thematically and cover a broad array of solutions in diverse countries including India, Bangladesh, Vietnam, Tanzania, the United States, South Africa, Mozambique, Peru, Ghana, Haiti,and Mexico. Specific programs for alleviating—or even eradicating—poverty through profitable partnerships come from myriad sectors such as banking, health, education, infrastructure development, environment, and technology. The cases highlight solutions that focus on bringing about substantive shifts in the conditions of life for those living in poverty.