This volume constitutes the refereed proceedings of the 22st EuroSPI conference, held in Ankara, Turkey, in September/October 2015. The 18 revised papers presented together with 9 selected key notes and workshop papers were carefully reviewed and selected from 49 submissions. They are organized in topical sections on SPI themed case studies; SPI approaches in safety-critical domains; SPI in social and organizational issues; software process improvement best practices; models and optimization approaches in SPI; SPI and process assessment; creating environments supporting innovation and improvement; social aspects of SPI: conflicts, games, gamification and other social approaches; risk management and functional safety management.