This book addresses the need for a fundamental understanding of the physical origin, the mathematical behavior, and the numerical treatment of models which include microstructure. Leading scientists present their efforts involving mathematical analysis, numerical analysis, computational mechanics, material modelling and experiment. The mathematical analyses are based on methods from the calculus of variations, while in the numerical implementation global optimization algorithms play a central role. The modeling covers all length scales, from the atomic structure up to macroscopic samples. The development of the models ware guided by experiments on single and polycrystals, and results will be checked against experimental data.