This book constitutes the refereed joint proceedings of the 4th International Workshop on Computer Assisted and Robotic Endoscopy, CARE 2017, and the 6th International Workshop on Clinical Image-Based Procedures: Translational Research in Medical Imaging, CLIP 2017, held in conjunction with the 20th International Conference on Medical Imaging and Computer-Assisted Intervention, MICCAI 2017, in Québec City, QC, Canada, in September 2017. The 7 full papers presented at CARE 2017 and the 10 full papers presented at CLIP 2017 were carefully reviewed and selected. The papers deal with interventional and diagnostic endoscopy integrating the latest advances in computer vision, robotics, medical imaging and information processing and the development and evaluation of new translational image-based techniques in the modern hospital.  .