This book constitutes the refereed proceedings of the 13th International Conference on Engineering Psychology and Cognitive Ergonomics, EPCE 2016, held as part of the 18th International Conference on Human-Computer Interaction, HCII 2016, held in Toronto, ON, Canada, in July 2016. The total of 1287 regular papers and 186 poster papers presented at the HCII 2016 conferences was carefully reviewed and selected from 4354 submissions. These papers address the latest research and development efforts and highlight the human aspects of design and use of computing systems. The papers accepted for presentation thoroughly cover the entire field of human-computer interaction, addressing major advances in knowledge and effective use of computers in a variety of application areas. The 47 contributions included in the EPCE proceedings were organized in the following topical sections: mental workload and performance; interaction and cognition; team cognition; cognition in complex and high risk environments; and cognition in aviation.