This book constitutes the refereed proceedings of the 14th IFIP WG 12.5 International Conference on Artificial Intelligence Applications and Innovations, AIAI 2018, held in Rhodes, Greece, in May 2018. The 42 full papers and 12 short papers were carefully reviewed and selected from 88 submissions. They are organized in the following topical sections: social media, games, ontologies; deep learning; support vector machines; constraints; machine learning, regression, classification; neural networks; medical intelligence; recommender systems; optimization; learning, intelligence; heuristic approaches, cloud; fuzzy; and human and computer interaction, sound, video, processing.