Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies
tarafından
Bi, Yunchen. author.
Başlık
:
Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies
Yazar
:
Bi, Yunchen. author.
ISBN
:
9783662546185
Yazar
:
Bi, Yunchen. author.
Edisyon
:
1st ed. 2018.
Fiziksel Niteleme
:
XII, 79 p. 41 illus. online resource.
Seri
:
Springer Theses, Recognizing Outstanding Ph.D. Research,
İçindekiler
:
Introduction -- Review -- Nanodisc assembly and the study on the interaction between the lipid and ion -- Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation -- The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin -- Summary and prospect of this dissertation.
Özet
:
This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.
Konu Başlığı
:
Biomedical engineering.
Cell membranes.
Immunology.
Biomedical Engineering and Bioengineering. http://scigraph.springernature.com/things/product-market-codes/T2700X
Biological and Medical Physics, Biophysics. http://scigraph.springernature.com/things/product-market-codes/P27008
Membrane Biology. http://scigraph.springernature.com/things/product-market-codes/L16050
Immunology. http://scigraph.springernature.com/things/product-market-codes/B14000
Atomic/Molecular Structure and Spectra. http://scigraph.springernature.com/things/product-market-codes/P24017
Ek Kurum Yazar
:
SpringerLink (Online service)
Elektronik Erişim
:
Materyal Türü | Barkod | Yer Numarası | Durumu/İade Tarihi |
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Electronic Book | 223570-1001 | R856 -857 | Springer E-Book Collection |