This book constitutes the refereed proceedings of the First International Conference on Computer-Human Interaction Research and Applications, CHIRA 2017, held in Funchal, Madeira, Portugal, in October/November 2017. The 8 full papers presented in this book were carefully reviewed and selected from 35 submissions. The papers selected to be included in this book contribute to the understanding of relevant trends of current research on computer-human interaction, including Interaction design, human factors, entertainment, cognition, perception, user-friendly software and systems, pervasive technologies and interactive devices.