Trustworthiness is a key success factor in the acceptance and adoption of cyber-physical systems. The author first discusses various existing definitions of trust and trustworthiness and extends them to cyber-physical systems. A comprehensive framework is proposed, including methods that cover all phases of development: requirements engineering, system design, trustworthiness evaluation, run-time maintenance, and evidence-based assurance. To support a smooth integration of the methods into development projects, these methods are provided in the form of so-called capability patterns. A running example from the ambient assisted living domain is used to demonstrate the application of the methods. Contents Methods for Addressing Trustworthiness in Development Methodologies Analysis and Documentation of Trustworthiness Requirements and Trust Concerns Trustworthiness Evaluation and Maintenance Evidence-Based Trustworthiness Using Trustworthiness Cases Target Groups Scientists and students in the field of system and software engineering, quality assurance, digitalization and business application development Project managers, software engineers, software architects and system analysts About the Author Nazila Gol Mohammadi is currently working as an associate researcher at paluno – The Ruhr Institute for Software Technology in Essen, Germany. Her research interests include software engineering, requirements engineering, digitalization, cloud computing, cyber-physical systems, and trustworthiness of software systems.