This book constitutes the refereed proceedings of the 6th International Conference on Information Technology in Bio- and Medical Informatics, ITBAM 2015, held in Valencia, Spain, in September 2015, in conjunction with DEXA 2015. The 9 revised long papers presented together with 1 poster paper were carefully reviewed and selected from 15 submissions. The papers address the following two topics: medical terminology and clinical processes and machine learning in biomedicine.