This book constitutes the refereed proceedings of the 15th International Symposium on Neural Networks, ISNN 2018, held in Minsk, Belarus in June 2018. The 98 revised regular papers presented in this volume were carefully reviewed and selected from 214 submissions. The papers cover many topics of neural network-related research including intelligent control, neurodynamic analysis, bio-signal, bioinformatics and biomedical engineering, clustering, classification, forecasting, models, algorithms, cognitive computation, machine learning, and optimization.