This book constitutes the refereed proceedings of the IFIP TC 5, WG 8.4, 8.9, 12.9 International Cross-Domain Conference for Machine Learning and Knowledge Extraction, CD-MAKE 2018, held in Hamburg, Germany, in September 2018. The 25 revised full papers presented were carefully reviewed and selected from 45 submissions. The papers are clustered under the following topical sections: MAKE-Main Track, MAKE-Text, MAKE-Smart Factory, MAKE-Topology, and MAKE Explainable AI. .