This book constitutes the refereed proceedings of the 4th International Conference on Mining Intelligence and Knowledge Exploration, MIKE 2016, held in Mexico City, Mexico, in November 2016. The 18 full papers presented were carefully reviewed and selected from 56 submissions. Accepted papers were grouped into various subtopics including information retrieval, machine learning, pattern recognition, knowledge discovery, classification, clustering, image processing, network security, speech processing, natural language processing, language, cognition and computation, fuzzy sets, and business intelligence.